p75 NGF Receptor (NGFR) (1-160) Mouse Monoclonal Antibody [Clone ID: NGFR5]

CAT#: AM00235BT-N

p75 NGF Receptor (NGFR) (1-160) mouse monoclonal antibody, clone NGFR5, Biotin

Product Images

Surface staining (mass cytometry) of brain tumor cells with anti-CD271 (NGFR5) 143Nd. Gated on singlets.

Specifications

Product Data

• Clone Name: NGFR5
• Applications: FC
• Recommended Dilution: Indirect immunofluorescence analysis by Flow cytometry: 1:200 as starting point.
• Reactivities: Feline, Ferret, Human, Primate, Rabbit
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified CD271 protein isolated from human melanoma cell line A875
• Specificity: This antibody recognizes CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160.
• Formulation: Phosphate buffered saline (PBS)
  Label: Biotin
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: nerve growth factor receptor
• Database Link:
  Entrez Gene 4804 Human
• Background: CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
• Synonyms: TNFRSF16