Pdcd1lg2 Rat Monoclonal Antibody [Clone ID: TY25]

CAT#: AM01313PU-N

Pdcd1lg2 rat monoclonal antibody, clone TY25, Purified

Specifications

Product Data

• Clone Name: TY25
• Applications: FC, IHC, IP
• Recommended Dilution: Immunoprecipitation.
  Immunohistochemistry on frozen sections.
  Flow Cytometry: 1/100 - 1/200; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: B7-DC transfected RAW264.7 cells. Lymph node cells from immunised SD rats were fused with the cells of the P3U1 myeloma cell line.
• Specificity: This antiobdy recognises mouse CD273, a 42kD member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2).
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide
  State: Purified
  State: Liquid purified Ig
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Database Link:
  Entrez Gene 58205 Mouse
• Background: The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD279).
  Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. Antibodies produced by clone TY25 are reported to block the binding of CD273 (B7-DC) to it's receptor.
• Synonyms: PD-L2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1LG2, B7DC, PDCD1L2