Epstein Barr Virus / EBV LMP2A Rat Monoclonal Antibody [Clone ID: 15F9]

CAT#: AM01315PU-N

Epstein Barr Virus / EBV LMP2A rat monoclonal antibody, clone 15F9, Purified

Specifications

Product Data

• Clone Name: 15F9
• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/100-1/1000.
  Immunohistochemistry on Paraffin Sections: This product requires antigen retrieval using heat treatment methods prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Bacterial TrpE-LMP2A fusion protein.
• Specificity: This antibody recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) and does not cross react with LMP2B.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Background: EBV is a human herpesvirus, which is associated with conditions such as Hodgkins disease and Burkitts Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
• Synonyms: HHV4, HHV-4