CD51 / ITGAV Rat Monoclonal Antibody [Clone ID: RMV-7]

CAT#: AM05569PU-N

CD51 / ITGAV rat monoclonal antibody, clone RMV-7, Purified

Specifications

Product Data

• Clone Name: RMV-7
• Applications: FC, IHC, IP
• Recommended Dilution: Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 10e6 cells in 100 µl.
  Immunoprecipitation.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Cultured LAK cells from Balb/c mice.
• Specificity: This antibody recognizes CD51.
  The RMV-7 antibody has been reported to block binding of CD51 to Vitronectin, Fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity. We recommend the use of AM05569LE-N for this purpose.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Background: CD51 is a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the intergrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 functions as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.
• Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha