alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 2B2D1]
Specifications
Product Data | |
Clone Name | 2B2D1 |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of SNCA expressed in E. Coli. |
Specificity | Recognizes Alpha-synuclein (SNCA). |
Formulation | State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy. |
Synonyms | NACP, PARK1 |
Reference Data |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.