Cd40 Rat Monoclonal Antibody [Clone ID: 1C10]

CAT#: AM08042PU-N

Cd40 rat monoclonal antibody, clone 1C10, Purified


USD 320.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name 1C10
Applications FC, FN, IP
Recommended Dilution Flow Cytometry. (Ref.2)
Immunoprecipitation. (Ref.2)
Functional Assay: In vitro induction of proliferation of mature B lymphocytes. (Ref.2)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody is specific to Mouse CD40 (Mr. 45-50 kDa)
Formulation 100 mM Borate Buffered Saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
State: Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Background CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. (Ref.1-5) CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. (Ref.4) CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. (Ref.6)
The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors. (Ref.2)
Synonyms TNFRSF5, CDw40, Bp50
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.