Tfrc Rat Monoclonal Antibody [Clone ID: RI7217]

CAT#: AM08050PU-N

Tfrc rat monoclonal antibody, clone RI7217, Purified

Specifications

Product Data

• Clone Name: RI7217
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry. (Ref.1-3,5)
  In vivo and vitro Inhibition of Cell Proliferation. (Ref.2)
  Immunoprecipitation. (Ref.3)
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions).
  RI7217 inhibits cell proliferation in vitro. (Ref.2)
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Database Link:
  Entrez Gene 22042 Mouse
• Background: CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain.
• Synonyms: TfR1, p90, Transferrin receptor protein 1