Bcl-2-like 1 (Bcl-xL) Mouse Monoclonal Antibody [Clone ID: 7B2.5]

CAT#: AM08172FC-N

Bcl-2-like 1 (Bcl-xL) mouse monoclonal antibody, clone 7B2.5, FITC

Specifications

Product Data

• Clone Name: 7B2.5
• Applications: FC
• Recommended Dilution: Flow Cytometry: < / = 3 µg/10e6 cells.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG3
• Clonality: Monoclonal
• Immunogen: Recombinant Bcl-xS.
• Specificity: This antibody recognizes Bcl-xL.
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  Label: FITC
  State: Liquid purified Ig fraction.
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: 0.1 mg/ml
• Conjugation: FITC
• Background: Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (Ref.1) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (Ref.2) Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis (Ref.3,4) while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (Ref.5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. (Ref.9-13)
  In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2. (Ref.5,14)
  Other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity. (Ref.15,16)
• Synonyms: Bcl2-L-1, BCL2L1, BCL2L, BCLX, Bcl-x, bcl-xL, bcl-xS, Bcl-2-like protein 1