p27 KIP 1 (CDKN1B) Mouse Monoclonal Antibody [Clone ID: SX53G8]

CAT#: AM10127SU-N

p27 KIP 1 (CDKN1B) mouse monoclonal antibody, clone SX53G8, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human B-cell lymphoma stained with p27 antibody Cat.-No. AM10127SU-N using peroxidase conjugate and DAB chromogen. Note nuclear staining of tumor cells.

Specifications

Product Data

• Clone Name: SX53G8
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Colon carcinoma.
• Reactivities: Canine, Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified glutathione S-transferase (GST)-p27Kip1 fusion protein.
• Specificity: Recognizes p27Kip1.
  Clone SX53G8 co-precipitates cdk4 in complex with p27Kip1 and is excellent for staining of formalin fixed tissues.
  Cellular Localization: Nuclear.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Gene Name: Homo sapiens neurofilament, light polypeptide (NEFL)
• Database Link:
  Entrez Gene 18039 MouseEntrez Gene 83613 RatEntrez Gene 1027 Human
• Background: p27Kip1, a candidate tumor suppressor gene, functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF-beta induced G1 arrest.
• Synonyms: p27Kip1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Amyotrophic lateral sclerosis (ALS)