UBN1 (1-190) Mouse Monoclonal Antibody [Clone ID: UBN1-02]
CAT#: AM26039PU-N
UBN1 (1-190) mouse monoclonal antibody, clone UBN1-02, Aff - Purified
Other products for "UBN1"
Specifications
Product Data | |
Clone Name | UBN1-02 |
Applications | IP, WB |
Recommended Dilution | Immunoprecipitation. Western blot: 1-5 μg/ml; Positive control: HeLa cell line. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1 |
Specificity | This antibody recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band. |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Gene Name | Homo sapiens ubinuclein 1 (UBN1), transcript variant 1 |
Database Link | |
Background | Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density. |
Synonyms | VT; VT4 |
Reference Data |
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