LY75 (LY75-CD302) Mouse Monoclonal Antibody [Clone ID: HD30]

CAT#: AM26139PU-N

LY75 (LY75-CD302) mouse monoclonal antibody, clone HD30, Aff - Purified


USD 230.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name HD30
Applications FC, IHC, WB
Recommended Dilution Flow cytometry.
Western blot (only non-denatured samples).
Immunohistochemistry (frozen sections).
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant Fc-tagged human CD205
Specificity This antibody recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Aff - Purified
State: Liquid Ig fraction
Concentration 1.0 mg/ml
Purification Protein-A affinity chromatography; purity > 95% (by SDS-PAGE)
Gene Name Homo sapiens LY75-CD302 readthrough (LY75-CD302), transcript variant 1
Background CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
Synonyms LY75, CLEC13B, DEC205, gp200-MR6
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.