TLR2 Mouse Monoclonal Antibody [Clone ID: TL2.3]

CAT#: AM26265BT-N

TLR2 mouse monoclonal antibody, clone TL2.3, Biotin


USD 290.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Clone Name TL2.3
Applications ELISA, WB
Recommended Dilution Flow cytometry: The typical starting working dilution is 1:50.
Immunoassay.
Western blot: The typical starting working dilution is 1:50.
Reactivities Canine, Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Specificity

The TL2.3 monoclonal antibody is specific for human TLR2 (CD282). TL2.3 is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear cells.

Formulation PBS
Label: Biotin
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein G
Conjugation Biotin
Storage

Store at 2 - 8 °C.

Stability Shelf life: one year from despatch.

Gene Name toll like receptor 2
Background Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282).
Synonyms Toll-like receptor 2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.