Nectin2 (extracell. dom.) Rat Monoclonal Antibody [Clone ID: 502-57]

CAT#: AM26324PU-N

Nectin2 (extracell. dom.) rat monoclonal antibody, clone 502-57, Purified

Specifications

Product Data

• Clone Name: 502-57
• Applications: ELISA, IHC, IP, WB
• Recommended Dilution: Western blot.
  Flow Cytometry.
  Immunoassays.
  Immunoprecipitation.
  Immunohistochemitry on Frozen Sections.
  Recommendations: The typical starting working dilution is 1/10.
  Fixation with PFA or Acetone/Methanol is recommended.
• Reactivities: Human, Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Extracellular domain of Mouse Nectin-2
• Specificity: This antibody detects Nectin-2 at extracellular domain.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purification: Protein G Chromatography
• Database Link:
  Entrez Gene 19294 Mouse
• Background: Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines.
  The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.
• Synonyms: Nectin-2, PVRL2, HVEB, PRR2, Nectin-2