CD95 (FAS) Mouse Monoclonal Antibody [Clone ID: EOS9.1]
Product Images
Specifications
Product Data | |
Clone Name | EOS9.1 |
Applications | FC, FN |
Recommended Dilution | Flow cytometry. Functional application (in vitro induction of apoptosis). |
Reactivities | Human |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | P815 cells transfected with human CD95 |
Specificity | This antibody recognizes CD95 (Fas/APO-1), a 46 kDa glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. |
Formulation | Tris buffered saline (TBS) State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM sodium azide, approx. pH 8.0 |
Concentration | lot specific |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
Synonyms | FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6 |
Reference Data |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.