17-alpha-Hydroxyprogesterone / 17-OHP Mouse Monoclonal Antibody [Clone ID: HPRO-1]

CAT#: AM31544PU-N

17-alpha-Hydroxyprogesterone / 17-OHP mouse monoclonal antibody, clone HPRO-1, Purified

Specifications

Product Data

• Clone Name: HPRO-1
• Applications: ELISA
• Recommended Dilution: ELISA.
  Can be used in competitive assay of 17-alpha-Hydroxyprogesterone.
• Host: Mouse
• Isotype: IgG3
• Clonality: Monoclonal
• Immunogen: Conjugate of 17-alpha-hydroxyprogesterone with BSA
• Specificity: Reacts with 17-alpha-hydroxyprogesterone-BSA conjugate and free 17-alpha-hydroxyprogesterone.
  No cross reactivity with BSA.
  Cross reactivity:
  17-Hydroxyprogesterone: 100%
  Progesterone: 7%
  Deoxycorticosterone: 3%
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: lot specific
• Purification: Protein G Chromatography
• Storage: Store the antibody undiluted at 2-8°C .
• Stability: Shelf life: one year from despatch.
• Background:

  17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone produced during the synthesis of glucocorticoids and sex steroids. It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3-beta-hydroxysteroid dehydrogenase / Delta 5-4 isomerase. 17-Hydroxyprogesterone is a natural progestogen, and in pregnancy increases in the third trimester primarily due to fetal adrenal production. This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Hydroxyprogesterone has been used for recurrent miscarriage and various menstrual disorders. Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that hydroxyprogesterone may reduce the risk of preterm delivery.

• Synonyms: 17OHP, 17-Hydroxyprogesterone, 17-alpha-Hydroxy-Progesterone