PDZK1 (1-520) Mouse Monoclonal Antibody [Clone ID: 1C3-2B11]

CAT#: AM31814PU-N

PDZK1 (1-520) mouse monoclonal antibody, clone 1C3-2B11, Purified

Product Images

PDZK1 monoclonal antibody. Western Blot analysis of PDZK1 expression in human kidney.

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  Detection limit for recombinant GST tagged PDZK1 is approximately 0.03ng/ml as a capture antibody.

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1C3-2B11
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: PDZK1 antibody was raised against pDZK1 (AAH06496, 1 a.a. ~ 520 a.a) full length recombinant protein with GST tag.
• Specificity: This antibody reacts to full length PDZK1.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens PDZ domain containing 1 (PDZK1), transcript variant 2
• Database Link:
  Entrez Gene 5174 Human
• Background: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
• Synonyms: PDZK1, NHERF3, NHERF-3, NHE-RF3, NaPi-Cap1, CAP70