Cd46 Rat Monoclonal Antibody [Clone ID: MM10]

CAT#: AM32953PU-N

Cd46 rat monoclonal antibody, clone MM10, Purified

Specifications

Product Data

• Clone Name: MM10
• Applications: ELISA, FC, IF, WB
• Recommended Dilution: Immuno Assays (Detector)
  Positive Control: Rat CD46 or Mouse CD46 variant as coating on a micro titer plate.
  Western blot (Researcher data).
  Flow Cytometry (Researcher data)
  Immunefluorescence (Researcher data).
  Immuno histochemistry on Frozen Sections (Researcher data).
  The typical starting working dilution is 1/50.
• Reactivities: Mouse, Rat
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Mouse CD46-human Fc fusion protein.
• Specificity: The monoclonal antibody MM10 recognizes membrane cofactor protein (MCP), also known as CD46.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Database Link:
  Entrez Gene 17221 Mouse
• Background: MCP is a type I membrane glycoprotein that consists of four isoforms i.e. two C-isoforms (51-58 kDa) and two BC isoforms (59-68 kDa) which arise by alternative splicing of a single CD46 gene. Membrane cofactor protein is expressed on every cell and tissue, with the exception of erythrocytes. Membrane cofactor protein serves to down-regulate the activation of complement on host tissue. MCP is a cofactor for factor 1-mediated cleavage of C3b and C4b and this way serves to protect the host cell against autologous attack. MCP is a receptor for several pathogens including measles virus, group A Streptococcus pyogenes and pathogenic Neisseria.
• Synonyms: TLX, MIC10