NSMase2 (SMPD3) Rabbit Polyclonal Antibody

CAT#: AP05301SU-N

NSMase2 (SMPD3) rabbit polyclonal antibody, Purified

Product Images

Western blot using nSMase2 antibody on human brain lysate. Lysate used at 14 ug/lane. Antibody used at 10 ug/ml. Secondary antibody, mouse anti-rabbit HRP, used at 1:50k dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot (1-5 µg/ml).
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from human sphingomyelin phosphodiesterase 3
• Specificity: This antibody detects Sphingomyelin Phosphodiesterase 3.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: Lot specific
• Gene Name: Homo sapiens sphingomyelin phosphodiesterase 3 (SMPD3)
• Database Link:
  Entrez Gene 55512 Human
• Background: Sphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization. It is activated by unsaturated fatty acids and phosphatidylserine. it is predominantly expressed in the brain.
• Synonyms: Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase II, Neutral sphingomyelinase 2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism