Metabotropic Glutamate Receptor 8 (GRM8) Rabbit Polyclonal Antibody

CAT#: AP06143PU-N

Metabotropic Glutamate Receptor 8 (GRM8) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of mGluR8 antibody in extracts from mouse brain cells.

• 

  Immunohistochemistry (IHC) analyzes of mGluR8 antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 851-900 of Human mGluR-8.
• Specificity: This antibody detects endogenous levels of GluR8 protein.
  (region surrounding Gln871)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 100 kDa
• Gene Name: Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript variant 1
• Database Link:
  Entrez Gene 14823 MouseEntrez Gene 60590 RatEntrez Gene 2918 Human
• Background: GLuR-8 is a group III metabotropic glutamate receptor. In response to glutamate stimulation, GLuR-8 activates GTP-binding proteins that modulate second-messenger cascades. Alternative splicing of this integral membrane protein produces three isoforms: A, B, and C. Human GLuR-8 maps to q31.3-q32.1 of chromosome 7.
• Synonyms: Metabotropic glutamate receptor 8, GPRC1H

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction