Mitofusin 2 (MFN2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP20135PU-N

Mitofusin 2 (MFN2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry. AP20135PU-N MFN2 antibody staining of paraffin-embedded rat cardiac muscle tissue.

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  Western blot: AP20135PU-N MFN2 antibody staining Rat cardiac muscle tissue lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/50-1/1000
  Immunohistochemistry on Paraffin embedded Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rabbit, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: C-terminal sequence of Human Mitofusion-2
• Specificity: Recognizes Mitofusion 2/MFN2.
• Formulation: State: Aff - Purified
  State: Liquid purified IgG fraction.
• Concentration: 0.5 mg/ml
• Purification: Affinity Chromatography.
• Gene Name: Homo sapiens mitofusin 2 (MFN2), transcript variant 2
• Database Link:
  Entrez Gene 64476 RatEntrez Gene 170731 MouseEntrez Gene 9927 Human
• Background: Mitofusion 2 or MFN2 is an essential transmembrane GTPase which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 lead to Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.
• Synonyms: MFN2, CPRP1, KIAA0214

Reference Data

• Protein Families: Transmembrane