alpha Defensin 1 (DEFA1) Rabbit Polyclonal Antibody

CAT#: AP20627PU-N

alpha Defensin 1 (DEFA1) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry analyzes of Defensin alpha-1 antibody (Cat.-No AP20627PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Defensin α1 protein.
  (region surrounding Ser52)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens defensin alpha 1B (DEFA1B), transcript variant 2
• Database Link:
  Entrez Gene 728358 HumanEntrez Gene 1667 Human
• Background: β-Defensins (also designated BD, and HBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. β-defensins are involved in the resistance of epithelial surfaces, such as airway surface fluid, to microbial colonization. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. Human β-defensin 1, isolated from the kidney, has a molecular mass of 3.9 kDa. Human β-defensin 1 shares homology with other β-defensins from human blood filtrate and is also present in nanomolar concentrations in human plasma. In addition to the antimicrobial activity of human airway epithelia, β-defensin 1 may play a role in the mucosal defenses of the lung.
• Synonyms: Neutrophil defensin 1, HNP-1, DEFA1, DEF1, DEFA2, MRS

Reference Data

• Protein Families: Druggable Genome