p73 (TP73) (alpha) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23318PU-N

p73 (TP73) (alpha) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Hela cell lysis using P73alpha antibody

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  Immunohistochemical analysis of paraffin embedded HUman intestine cancer sections using P73alpha antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 1-2µg/ml with the appropriate system to detect P73ain cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2µg/ml to detect P73ain formalin fixed and paraffin embedded tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A peptide mapping at the C-terminal end of human P73a
• Specificity: This antibody detects Tumor protein p73 (alpha) at C-term.
• Formulation: 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tumor protein p73 (TP73), transcript variant 2
• Database Link:
  Entrez Gene 362675 RatEntrez Gene 7161 Human
• Background: p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation. Moreover, p73 was phosphorylated in vivo in response to ionizing radiation. p73, a member of the p53 family of tumour-suppressor proteins, can also induce apoptosis.p73 gene is mapped to chromosome 1p36. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
• Synonyms: OTTHUMP00000003479; OTTHUMP00000003480; P73

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Neurotrophin signaling pathway, p53 signaling pathway