RAGE (AGER) Rabbit Polyclonal Antibody

CAT#: AP23365PU-N

RAGE (AGER) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat lung tissue lysis using RAGE antibody

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  Immunohistochemical analysis of Paraffin-Embedded Rat Tissue Sections (Lung) using RAGE antibody.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1.0-2.0 μg/ml with the appropriate system to detect RAGE in cells and tissues.
  
  Immunohistochemistry on Paraffin Sections: 0.5-1 μg/ml to detect RAGE in formalin fixed and paraffin embedded tissues. Antigen Retrieval by Heat is recommended.
  This product can also be used on frozen sections at the same concentration.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence mapping in the middle region of Human advanced glycosylation end-product-specific receptor(RAGE), different from the related Mouse and Rat sequences by two amino acids.
• Specificity: This antibody detects RAGE / AGER.
  No cross reactivity with other proteins.
• Formulation: 5 mg BSA, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide
  State: Aff - Purified
  State: Lyophilized purified Ig fraction
• Reconstitution Method: 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens advanced glycosylation end product-specific receptor (AGER), transcript variant 1
• Database Link:
  Entrez Gene 11596 MouseEntrez Gene 81722 RatEntrez Gene 177 Human
• Background: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
• Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane