GPR44 (PTGDR2) (329-348) Rabbit Polyclonal Antibody

CAT#: AP23568PU-N

GPR44 (PTGDR2) (329-348) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human GPR44 / CRTH2 (aa 329-348)
• Specificity: This antibody reacts to G Protein-Coupled Receptor GPR44 (CRTH2) at aa 329-348.
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens prostaglandin D2 receptor 2 (PTGDR2)
• Database Link:
  Entrez Gene 14764 MouseEntrez Gene 309212 RatEntrez Gene 11251 Human
• Background: GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
• Synonyms: CRTH2, DL1R, PTGDR2, Prostaglandin D2 receptor 2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane