TRAF6 Rabbit Polyclonal Antibody

CAT#: AP26352PU-N

TRAF6 rabbit polyclonal antibody, Aff - Purified

Product Images

: Western blot analysis of TRAF6 in 3T3 cell lysate (Lane 1) and in Jurkat cell lysate (Lane 2 & 3).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot (0.5-4 µg/ml).
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 436 of rat TRAF6
• Specificity: This antibody recognizes 54 kDa TRAF6.
• Formulation: Phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity chromatography
• Gene Name: Homo sapiens TNF receptor associated factor 6 (TRAF6), transcript variant 2
• Database Link:
  Entrez Gene 22034 MouseEntrez Gene 311245 RatEntrez Gene 7189 Human
• Background: TRAFs (TNF receptor associated proteins) form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6. Mice deficient in TRAF6 are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function. Like TRAF2 and TRAF3, TRAF6 is also essential for perinatal and postnatal survival. These findings establish diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling.
• Synonyms: TNF receptor-associated factor 6

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway, Ubiquitin mediated proteolysis