MMP11 (61-110) Rabbit Polyclonal Antibody

CAT#: AP31345PU-N

MMP11 (61-110) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from A549 cells, using MMP-11 Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of A549 cells, using MMP-11 Antibody. The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/20000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/100.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from Human MMP-11 (aa61-110)
• Specificity: This antibody detects endogenous levels of total MMP-11 protein (aa61-110).
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens matrix metallopeptidase 11 (MMP11), transcript variant 1
• Database Link:
  Entrez Gene 17385 MouseEntrez Gene 25481 RatEntrez Gene 4320 Human
• Background: MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.
• Synonyms: MMP11, Stromelysin-3, SL-3, ST3, STMY3, Matrix metalloproteinase-11

Reference Data

• Protein Families: Druggable Genome, Protease