Desmoglein 1 (DSG1) Goat Polyclonal Antibody
Other products for "DSG1"
Specifications
Product Data | |
Applications | ELISA, IHC |
Recommended Dilution | Peptide ELISA: Detection Limit: 1/32000. Western Blot: Preliminary experiments in lysates of cell lines A431, HeLa, K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Immunohistochemistry on Paraffin Sections: 4-6 µg/ml. In Paraffin Embedded Human Skin shows staining of the cellular membranes of keratinocytes. |
Reactivities | Human |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide with sequence from the internal region of the protein sequence according to NP_001933.2. |
Specificity | Recognizes Desmoglein 1 / DSG1 |
Formulation | Tris saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens desmoglein 1 (DSG1) |
Database Link | |
Background | Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. Desmoglein 1 is a 165kD glycoprotein that is a core component of the desmosome cell-cell junction between epithelial cells. Desmoglein 1 is synthesized in the suprabasal layer of the skin, and is vital to epidermal integrity. |
Synonyms | Desmosomal glycoprotein 1, Pemphigus foliaceus antigen, DSG1, CDHF4, DG1, DGI |
Reference Data | |
Protein Families | Druggable Genome |
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