Deformed Epidermal Autoregulatory Factor 1 (DEAF1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51228PU-N

Deformed Epidermal Autoregulatory Factor 1 (DEAF1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of DEAF1 Antibody (C-term) in 293 cell line lysates (35ug/lane). This demonstrates the DEAF1 antibody detected the DEAF1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human DEAF1
• Specificity: This antibody recognizes Human DEAF1 (C-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
  
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens DEAF1, transcription factor (DEAF1), transcript variant 1
• Database Link:
  Entrez Gene 10522 Human
• Background:
  Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.
• Synonyms: SPN, ZMYND5, Suppressin, SPN, NUDR
• Note: Molecular Weight: 59327 Da

Reference Data

• Protein Families: Secreted Protein, Transcription Factors, Transmembrane