CD105 (ENG) (Center) Rabbit Polyclonal Antibody

CAT#: AP51429PU-N

CD105 (ENG) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ENG (arrow) using CD105 / Endoglin Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ENG gene.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 272-302 amino acids from the Central region of Human CD105 / Endoglin.
• Specificity: This antibody recognizes Human CD105 / Endoglin (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens endoglin (ENG), transcript variant 2
• Database Link:
  Entrez Gene 2022 Human
• Background: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: ENG, END, HHT1, ORW, ORW1
• Note: Molecular Weight: 70578 Da

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane