Macro H2A.2 (H2AFY2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP51990PU-N

Macro H2A.2 (H2AFY2) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of H2AFY2 / MACROH2A2 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). This demonstrates the H2AFY2 antibody detected the H2AFY2 protein (arrow).

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  Flow cytometric analysis of Hela cells using H2AFY2 / MACROH2A2 Antibody (N-term) (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of Human H2AFY2 / MACROH2A2
• Specificity: This antibody recognizes Human and Mouse H2AFY2 / MACROH2A2 (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens H2A histone family member Y2 (H2AFY2)
• Database Link:
  Entrez Gene 404634 MouseEntrez Gene 55506 Human
• Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
• Synonyms: Core histone macro-H2A.2, Histone macroH2A2, mH2A2
• Note: Molecular Weight: 40058 Da

Reference Data

• Protein Pathways: Systemic lupus erythematosus