PDZK1 (Center) Rabbit Polyclonal Antibody

CAT#: AP53250PU-N

PDZK1 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PDZK1 Antibody (Center) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PDZK1 antibody detected the PDZK1 protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with PDZK1 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human PDZK1
• Specificity: This antibody recognizes Human PDZK1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens PDZ domain containing 1 (PDZK1), transcript variant 2
• Database Link:
  Entrez Gene 5174 Human
• Background: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
• Synonyms: PDZK1, NHERF3, NHERF-3, NHE-RF3, NaPi-Cap1, CAP70
• Note: Molecular Weight: 57129 Da