SH3BP2 (Center) Rabbit Polyclonal Antibody

CAT#: AP53901PU-N

SH3BP2 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis using SH3BP2 Antibody (Center) in Mouse spleen tissue lysates (35ug/lane).This demonstrates the SH3BP2 antibody detected the SH3BP2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 150-180 amino acids from the Central region of Human SH3BP2
• Specificity: Recognizes SH3BP2 (Center).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens SH3 domain binding protein 2 (SH3BP2), transcript variant 2
• Database Link:
  Entrez Gene 24055 MouseEntrez Gene 6452 Human
• Background: The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: SH3 domain-binding protein 2, SH3BP-2, 3BP2, 3BP-2
• Note: Molecular Weight: 62244 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity