SIGLEC5 (N-term) Rabbit Polyclonal Antibody

CAT#: AP53917PU-N

SIGLEC5 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CD170 / SIGLEC5 Antibody in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of Human SIGLEC5.
• Specificity: This antibody recognizes Human CD170 / SIGLEC5 (N-term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5)
• Database Link:
  Entrez Gene 8778 Human
• Background:
  The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).
• Synonyms: CD33L2, OBBP2, OB-binding protein 2, Siglec-5
• Note: Molecular Weight: 60715 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane