Syntrophin (SNTB2) (Center) Rabbit Polyclonal Antibody

CAT#: AP53969PU-N

Syntrophin (SNTB2) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in MCF-7 cell line lysates (35ug/lane) using Syntrophin-3 / SNTB2 antibody.This demonstrates the Syntrophin-3 antibody detected the Syntrophin-3 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: This antibody is suitable for Western blotting.
  The suggested dilution is: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 216-245aa) of human Syntrophin-3 / SNTB2.
• Specificity: This antibody detects human Syntrophin-3 / SNTB2.
• Formulation: PBS with 0.09% (W/V) Sodium Azide.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column,; followed by peptide affinity purification.
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens syntrophin beta 2 (SNTB2)
• Database Link:
  Entrez Gene 6645 Human
• Background: Syntrophins are structurally related proteins located at the neuromuscular synapse and play an important role in dystrophin associated protein (DAP) complex formation. To date there have been three distinct syntrophin isoforms discovered: alpha 1, beta 1, and beta 2. These proteins each contain a PDZ domain, a syntrophin-unique domain (SU), and three pleckstrin homology domains (PH1a,1b and 2). The PDZ domain has been shown to be responsible for binding syntrophin to nNOS and the DAP complex. This association results in localization of the nicotinic acetylcholine receptor to the cytoskeleton via the (S/T)XV C terminus.
  
  
• Synonyms: SNT3, Beta-2-syntrophin, Syntrophin-like, SNTL, SNT2B2
• Note: Molecular Weight: 57950 Da

Reference Data

• Protein Families: Secreted Protein