CD41-CD61 Complex Mouse Monoclonal Antibody [Clone ID: M148]

CAT#: BM2608B

CD41-CD61 Complex mouse monoclonal antibody, clone M148, Biotin

Specifications

Product Data

• Clone Name: M148
• Applications: FC
• Recommended Dilution: Suitable for use in Flow Cytometric applications: 1 µg to stain 1.0 x 10e6 cells.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: Anti-Human CD41 recognizes an epitope on the gpIIb/IIIa complex on the surface membrane of human platelets. (1)
  Precipitates two bands under non-reducing conditions (Mr 110 kDa and 130 kDa).
• Formulation: 0.01 M PBS, pH 7.2, containing 2.0 mM EDTA and 1.0% BSA as buffer and 0.09% Sodium Azide as preservative.
  Label: Biotin
  State: Liquid purified Ig fraction.
  Label: Conjugated to Biotin.
• Concentration: lot specific
• Purification: Protein G chromatography.
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE !
• Stability: Shelf life: one year from despatch.
• Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
• Synonyms: GPIIb-IIIa, ITGA2B, GP2B, ITGAB, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, GP3A, CD41, CD61, Integrin alpha-IIb, Integrin beta-3, ITGB3
• Note: The CD41 antigen is present on virtually all human platelets and is also found on megakaryocytes.