CD40 Mouse Monoclonal Antibody [Clone ID: G28-5]

CAT#: DDX0130P-100

CD40 mouse monoclonal antibody, clone G28-5

Product Images

IHC staining of formalin-fixed paraffin-embedded human cervical tissue with mAb G28.5 Altenburg A et al, J.Immunol, 1999. a: normal cervical epithelium b: cervical intraepithelial neoplasia c: squamous cell carcinoma

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  CD40-transfected L cells stained with G28.5 (DDX0130)

Specifications

Product Data

• Clone Name: G28-5
• Applications: FC, FN, IHC
• Recommended Dilution: Cell activation, IHC paraffin, flow cytometry.
  Usage recommendation: *This monoclonal antibody may be used between 1-10 μg/ml for cellular activation.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: human erythrocyte-rosette-negative tonsillar lymphocyte
• Specificity: human CD40
• Formulation: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8
  State: Purified
• Concentration: lot specific
• Purification: QMA Hyper D ion exchange chromatography
• Conjugation: Unconjugated
• Storage: -20°C. KEEP CONTENTS STERILE: no preservative.
  Purified antibodies: avoid repeated freeze/thaw cycles.
  Coupled antibodies: glycerol protects from freezing.
• Gene Name: CD40 molecule
• Database Link:
  Entrez Gene 958 Human
  UniProt ID P25942
• Background: CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand expressed on activated CD4+ T cells. Clark E.A. et al. have reported a mAb binding to a 50 kDa B-cell surface marker (BP50) which augments B-cell activation and proliferation. This B-cell marker was CD40. (Clark E.A.. et al, 1985 ; PNAS, 82 :1766 ; Clark E.A. et al, 1986 ; PNAS, 83 : 4494-4498)
• Synonyms: TNFRSF5, CDw40, Bp50