RAGE / AGER (Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: 2B65]

CAT#: DM3593P

RAGE / AGER (Extracell. Dom.) rat monoclonal antibody, clone 2B65, Purified

Specifications

Product Data

• Clone Name: 2B65
• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on Frozen Sections: 1/50-1/100.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2
• Clonality: Monoclonal
• Immunogen: Mouse Recombinant RAGE extracellular domain.
• Specificity: This antibody detects Mouse RAGE in Western Blotting.
  Other species not tested.
• Formulation: Sterile PBS
  State: Purified
  State: Lyophilized (0.2 µm filtered) purified Ig fraction
  Preservative: None
• Reconstitution Method: Restore with 200 µl sterile PBS and the final concentration is 500 µg/ml.
• Concentration: 0.5 mg/ml (after reconstitution)
• Purification: Protein G Affinity Chromatography
• Background: The Receptor for Advanced Glycation Endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands. Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders. RAGE is expressed by endothelium mononuclear phagocytes, smooth muscle and neurons.
• Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products