LOX Rabbit Polyclonal Antibody

CAT#: TA301449

Rabbit Polyclonal Antibody against LOX

Product Images

Western Blot: LOX Antibody TA301449 - Analysis of LOX in human kidney using TA301449.

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  Immunocytochemistry/Immunofluorescence: LOX Antibody TA301449 - LOX antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

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  Simple Western: LOX Antibody TA301449 - Simple Western shows a specific band for LOX in 1.0 mg/ml of HeLa cell lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

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  Immunohistochemistry: LOX Antibody TA301449 - Staining of LOX in mouse stomach.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Knockdown Validated, Immunohistochemistry: 1:100-1:250, Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot: 0.5-4ug/ml, Immunohistochemistry-Paraffin: 1:100-1:250, Simple Western: 1:25
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an internal region of the human LOX protein (within residues 200-300). [Swiss-Prot P28300]
• Formulation: Tris-glycine, 150mM NaCl and 0.05% sodium azide
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lysyl oxidase
• Database Link:
  NP_002308
  Entrez Gene 16948 MouseEntrez Gene 4015 Human
  UniProt ID P28300
• Background: Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
• Synonyms: MGC105112

Reference Data

• Protein Families: Druggable Genome, Secreted Protein