Lox Rabbit Polyclonal Antibody

CAT#: TA301450

Rabbit Polyclonal Antibody against LOX

Product Images

Detection of LOX protein, Lane 1: Twice extracted guanidine hydrochloride mouse tibia/fibula lysate., Lane 2: normal rabbit serum

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  Staining of LOX in mouse spleen

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:4000
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Two synthetic peptides (a.a. 181-196 and 293-309) of the rat LOX protein.
• Formulation: 0.1% sodium azide
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lysyl oxidase
• Database Link:
  NP_058757
  Entrez Gene 16948 MouseEntrez Gene 24914 Rat
  UniProt ID P16636
• Background: Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
• Synonyms: MGC105112