TIRAP Rabbit Polyclonal Antibody

CAT#: TA306132

Rabbit Polyclonal TIRAP Antibody

Product Images

Western blot analysis of TIRAP in MCF-7 cell lysate with TIRAP antibody at 4 ug/ml.

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  Immunohistochemistry of TIRAP in human heart tissue with TIRAP antibody at 20 ug/ml.

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  Immunofluorescence of TIRAP in Human Heart cells with TIRAP antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 4 ug/mL, ICC: 20 ug/mL, IF: 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Ion exchange chromatography purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
• Database Link:
  NP_001034750
  Entrez Gene 114609 Human
  UniProt ID P58753
• Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7)
• Synonyms: BACTS1; Mal; MyD88-2; wyatt

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway