SLITRK6 Rabbit Polyclonal Antibody

CAT#: TA306531

Rabbit Polyclonal Slitrk6 Antibody

Product Images

Western blot analysis of Slitrk6 in SK-N-SH cell lysate with Slitrk6 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemistry of Slitrk6 in human brain tissue with Slitrk6 antibody at 2.5 ug/ml.

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  Immunofluorescence of Slitrk6 in Human Brain cells with Slitrk6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Slitrk6 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Slitrk6.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SLIT and NTRK like family member 6
• Database Link:
  NP_115605
  Entrez Gene 239250 MouseEntrez Gene 290467 RatEntrez Gene 84189 Human
  UniProt ID Q9H5Y7
• Background: SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. At least two isoforms of Slitrk6 are known to exisit. This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
• Synonyms: DFNMYP

Reference Data

• Protein Families: Druggable Genome, Transmembrane