CDCA8 Rabbit Polyclonal Antibody

CAT#: TA306625

Rabbit Polyclonal CDCA8 Antibody

Product Images

Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of CDCA8 in rat kidney tissue with CDCA8 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CDCA8 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CDCA8.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cell division cycle associated 8
• Database Link:
  NP_060571
  Entrez Gene 52276 MouseEntrez Gene 500545 RatEntrez Gene 55143 Human
  UniProt ID Q53HL2
• Background: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
• Synonyms: BOR; BOREALIN; DasraB; MESRGP

Reference Data

• Protein Families: Druggable Genome