STK39 Rabbit Polyclonal Antibody

CAT#: TA306666

Rabbit Polyclonal Stk39 Antibody

Product Images

Western blot analysis of Stk39 in SK-N-SH cell lysate with Stk39 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of Stk39 in human brain tissue with Stk39 antibody at 2.5 ug/ml.

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  Immunofluorescence of stk39 in human brain tissue with stk39 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Stk39 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human Stk39.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: serine/threonine kinase 39
• Database Link:
  NP_037365
  Entrez Gene 53416 MouseEntrez Gene 27347 Human
  UniProt ID Q9UEW8
• Background: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.
• Synonyms: DCHT; PASK; SPAK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase