GNPDA1 Rabbit Polyclonal Antibody

CAT#: TA306732

Rabbit Polyclonal GNPDA1 Antibody

Product Images

Western blot analysis of GNPDA1 in mouse kidney lysate with GNPDA1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of GNPDA1 in 293 cells with GNPDA1 antibody at 5 ug/mL.

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  Immunofluorescence of GNPDA1 in 293 cells with GNPDA1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GNPDA1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human GNPDA1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glucosamine-6-phosphate deaminase 1
• Database Link:
  NP_005462
  Entrez Gene 26384 MouseEntrez Gene 683570 RatEntrez Gene 10007 Human
  UniProt ID P46926
• Background: Glucosamine-6-phosphate deaminase (GNPDA) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. GNPDA1 is one of two mammalian glucosamine-6-phosphate deaminases that are thought to have arisen though gene duplication, with the GNPDA2 protein closer in structure and activity to the E. coli enzyme. GNPDA1 possesses greater affinity for ammonium than either GNPDA2 or the E. coli enzyme suggesting that the forward reaction of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium is catalyzed at a slower rate than GNPDA2. GNPDA1 is predicted to not cross-react with GNPDA2.
• Synonyms: GNP1; GNPDA; GNPI; GPI; HLN

Reference Data

• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Metabolic pathways