FKBP38 (FKBP8) Rabbit Polyclonal Antibody

CAT#: TA319236

Rabbit polyclonal anti-FKBP8 antibody

Product Images

WB using anti-FKBP8 antibody shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (lane 1). The results of peptide competition are shown in lane 2 where no specific staining is noted after the antibody is first incubated for 1h with the immunizing peptide in 5% BLOTTO prior to reaction with the membrane. The membrane was probed with the primary antibody at a 1:1,000 dilution in 5% BLOTTO at 4°C, overnight. Personal Communication, Olga Aprelikova, CCR-NCI, Bethesda, MD.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:25,000, WB: 1:500 - 1:2,000, IHC: User Optimized
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human FKBP8 protein.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: FK506 binding protein 8
• Database Link:
  NP_036313
  Entrez Gene 14232 MouseEntrez Gene 290652 RatEntrez Gene 23770 Human
  UniProt ID Q14318
• Synonyms: FKBP38; FKBPr38
• Note: This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. FKBP8 (also known as FK506-binding protein 38) is a member of the immunophilin family that has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP8 by RNAi or transfection of a mutant FKBP8 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP8 may play

Reference Data

• Protein Families: Druggable Genome, Transmembrane