NCLN Rabbit Polyclonal Antibody

CAT#: TA319970

Rabbit Polyclonal NCLN Antibody

Product Images

Western blot analysis of NCLN in mouse heart tissue lysate with NCLN antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of NCLN in human heart tissue with NCLN antibody at 2.5 ug/mL.

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  Immunofluorescence of NCLN in human heart tissue with NCLN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN.
• Formulation: NCLN Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NCLN Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nicalin
• Database Link:
  NP_064555
  Entrez Gene 103425 MouseEntrez Gene 314648 RatEntrez Gene 56926 Human
  UniProt ID Q969V3
• Background: NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
• Synonyms: NET59

Reference Data

• Protein Families: Transmembrane