Il21r Rat Monoclonal Antibody [Clone ID: eBio4A9]

CAT#: TA320367

Rat Anti-Mouse IL-21 Receptor Purified (100 ug)

Product Images

Staining of 2-day Anti-Mouse CD3e Functional Grade Purified stimulated BALB/c splenocytes with Anti-Mouse CD4 APC and 0.25 ug of Rat IgG2a kappa Isotype Control Purified (left) or 0.25 ug of Anti-Mouse IL-21 Receptor Purified (right) followed by Anti-Rat IgG Biotin and then Streptavidin PE. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: eBio4A9
• Applications: FC
• Recommended Dilution: Flow
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 21 receptor
• Database Link:
  NP_068687
  Entrez Gene 60504 Mouse
  UniProt ID Q9JHX3
• Background: The IL-21 receptor (IL-21R) combines with the common γ-chain to form a functional receptor for IL-21. IL-21R is expressed on several lineages including both resting and activated B, T, natural killer and dendritic cells. Binding of its ligand, IL-21, in these cells results in the activation of the Jak/Stat signal transduction pathway. The biological effects of ligand binding are diverse and depend on the cellular context and differentiation state of the cell. In the mouse, IL-21 binding to IL-21R induces the apoptosis of resting and activated B cells, enhances anti-CD3-mediated proliferation of T cells, and inhibits the maturation of dendritic cells and the IL-15-mediated expansion of NK cells.
• Synonyms: IL-21R; MGC10967; NILR