DOK1 Rabbit Polyclonal Antibody

CAT#: TA324070

Anti-DOK1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human hepatocellsular carcinoma tissue and Jurkat cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 300 amino acids of human docking protein 1, 62kDa (downstream of tyrosine kinase 1)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: docking protein 1
• Database Link:
  NP_001184189
  Entrez Gene 13448 MouseEntrez Gene 312477 RatEntrez Gene 1796 Human
  UniProt ID Q99704
• Background: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
• Synonyms: P62DOK

Reference Data

• Protein Families: Druggable Genome