KCNMB3 Mouse Monoclonal Antibody [Clone ID: S40B-18]

CAT#: TA326402

Mouse monoclonal BK Beta3a Antibody

Product Images

Western blot analysis of BKBeta3a in rat brain membrane lysates using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: S40B-18
• Applications: WB
• Recommended Dilution: WB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily M regulatory beta subunit 3
• Database Link:
  NP_741979
  Entrez Gene 310303 RatEntrez Gene 100502876 MouseEntrez Gene 27094 Human
  UniProt ID Q9NPA1
• Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release . A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia . This has major implications on other physiological processes in tissues other than the brain.
• Synonyms: BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3
• Note: Detects ~32 kDa. No cross-reactivity against BKBeta1, BKBeta1, BKBeta3b or BKBeta4.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction