Bcan Mouse Monoclonal Antibody [Clone ID: S294A-6]
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Specifications
Product Data | |
Clone Name | S294A-6 |
Recommended Dilution | WB: 1:1000 |
Reactivities | Mouse, Rat |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Fusion protein amino acids 219-655 of rat Brevican |
Formulation | PBS pH7.4, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | brevican |
Database Link | |
Background | Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adultbrain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bearchondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD Nterminal fragment is formed that contains the unique Cterminal epitope EAMESE. |
Synonyms | BEHAB; brevican; CSPG7; MGC13038 |
Note | Detects ~140kDa (and smaller due to proteolytic cleavage) |
Reference Data |
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